John E. Hall
74th APS President (2001-2002)
John E. Hall
John Hall is the Guyton Professor and Chairman of Physiology and Biophysics and Director of the Center of Excellence in Cardiovascular-Renal Research at the University of Mississippi Medical Center. Hall received his doctorate in physiology with James Schwinghamer at Michigan State University in 1974 and did postdoctoral training at the University of Mississippi Medical Center with Arthur Guyton before joining the faculty in 1976. He was promoted to full professor in 1982 and appointed as department Chair in 1989.
Hall's major research interests include cardiovascular and renal physiology, mechanisms of hypertension, the renin-angiotensin system, obesity and insulin resistance, and modeling and computer simulation of the cardiovascular-renal systems. His early work demonstrated the importance of the direct intrarenal actions of angiotensin II (ANG II) in regulating renal tubular sodium reabsorption, renal-pressure natriuresis, and long-term blood pressure. His studies also found that ANG II, through its vasoconstrictor effects on efferent arterioles, plays an important role in feedback control of glomerular filtration. These studies provided the physiological basis for understanding why renin-angiotensin system blockade may cause severe decreases in glomerular filtration rate in patients with underperfused kidneys (e.g., in renal artery stenosis), whereas renin-angiotensin system blockade may be beneficial in lowering glomerular pressure and limiting glomerular injury in patients with overperfused kidneys (e.g., in diabetes). His laboratory also was the first to demonstrate that renal-pressure natriuresis plays a crucial role in maintaining sodium balance in several experimental models of hypertension and that increased arterial pressure occurs as an essential compensation for impaired kidney function and an inability to maintain sodium balance at normal arterial pressure. In recent years, his research has helped to unravel the renal and neurohumoral mechanisms that link obesity with hypertension and kidney disease. His research has been continuously funded by the National Heart, Lung and Blood Institute (NHLBI) since 1975, and he has been the principal investigator of a Program Project Grant from NHLBI since 1988.
Hall has authored or co-authored over 390 publications and has written or edited 11 books, including the Textbook of Medical Physiology, which he co-authors with Arthur Guyton. He is Chief Editor of The American Journal of Physiology: Regulatory, Integrative and Comparative Physiology and serves on the editorial boards of several international journals. He is past Chairman of the Council for High Blood Pressure Research, American Heart Association (AHA); Chair of the Committee of Scientific Councils, AHA; and President-Elect of the Inter-American Society of Hypertension. He also serves on the executive committee of The American Society of Hypertension and the Board of Directors of the AHA.
Hall has been an active member of APS since 1978. He is a member of the Water and Electrolyte Homeostasis Section, the Renal Section, and a Fellow of the Cardiovascular Section. He served as Chair, Treasurer, and Councillor of the Water and Electrolyte Homeostasis Section, as a member of APS Council in 1991, as Chair of SAC from 1997-2000, on the APS Strategic Planning Committees in 1992 and 2000, on the Long-Range Planning Committee, on the Task Force for Translational Research, on the Blue Ribbon Panel on APS Programming, and on several other committees of APS. Hall's awards include the Richard Bright Award of the American Society of Hypertension, the Harry Goldblatt Award of the American Heart Association, the Merck, Sharp and Dohme International Research Award from the International Society of Hypertension, the Lewis Dahl Award of the American Heart Association, the Marion Young Scholar Award of the American Society of Hypertension, the Ernest Starling Lectureship of the APS, The Burroughs Wellcome Fund Visiting Professor in Basic Medical Sciences, the Special Research Achievement Award of the AHA-Mississippi, an NIH Career Development Award, and the A.P. Barnard and Billy S. Guyton Distinguished Professorships of The University of Mississippi.