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Sunscreen Use Could Lead to Better Blood Vessel Health

New study finds chemical sun protection preserves nitric oxide levels to maintain vascular health

Orlando, Fla. (April 7, 2019)—A new study suggests that sunscreen protects the skin’s blood vessel function from harmful ultraviolet radiation (UVR) exposure by protecting dilation of the blood vessels. Perspiration on the skin may also provide protection to the skin’s blood vessels from sun damage. The findings will be presented today at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2019 in Orlando, Fla.

UVR from the sun has been well-documented as a contributing factor to skin cancer and premature skin aging. UVR has also been found to reduce nitric oxide-associated dilation of skin blood vessels (vasodilation) by reducing the amount of nitric oxide available in the skin. Nitric oxide is a compound essential for blood vessel health. Vasodilation of the skin’s blood vessels plays an important role in regulating body temperature and responding to heat stress, both locally in the skin and throughout the body.

Researchers from Pennsylvania State University studied the effect of UVR exposure with sunscreen or sweat on nitric oxide’s ability to promote vasodilation of skin blood vessels. Healthy young adults with light-to-medium skin tone were exposed to UVR on one arm while the other arm served as a control and did not receive UVR treatment. The dosage of UVR was roughly equivalent of spending an hour outside on a sunny day, but without the reddening of sunburn. Three sites on the UVR-exposed arm of each participant were randomly assigned one of three treatments:

  • one site received UVR only,
  • a second site received UVR with a chemical sunscreen on the skin, and
  • a third site received UVR with simulated sweat on the skin.

The UVR-only site was found to have less nitric oxide-associated vasodilation than in the control arm. However, the sunscreen- and sweat-treated sites did not show these reductions in nitric oxide-associated vasodilation. “Further, when sunscreen was applied prior to UVR, UVR exposure actually augmented [nitric oxide-associated vasodilation] compared to [the control arm], or when sweat was on the skin,” the research team wrote. “The presence of sunscreen or sweat on the skin may play a protective role against this effect [of UVR].”

“For those who spend a lot of time working, exercising or participating in other various activities outdoors, using sunscreen may protect not only against skin cancer, but also against reductions in skin vascular function,” wrote S. Tony Wolf, MA, first author of the study.

S. Tony Wolf, MA, of Pennsylvania State University, will present the poster “The modulating effects of sunscreen and simulated sweat on ultraviolet radiation-induced microvascular dysfunction in the human cutaneous vasculature” on Sunday, April 7, in the Exhibit Hall-West of the Orlando County Convention Center.

NOTE TO JOURNALISTS: To schedule an interview with a member of the research team, please contact the APS Communications Office or 301-634-7209. Find more research highlights in the APS Press Room.

About Experimental Biology 2019

Experimental Biology is an annual meeting comprised of more than 14,000 scientists and exhibitors from five sponsoring societies and multiple guest societies. With a mission to share the newest scientific concepts and research findings shaping clinical advances, the meeting offers an unparalleled opportunity for exchange among scientists from across the United States and the world who represent dozens of scientific areas, from laboratory to translational to clinical research.
 

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.