The American Physiological Society Press Release

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APS Contact: Donna Krupa

Email: dkrupa@the-aps.org

Phone: 301.634.7209

Twitter: @Phyziochick

Selected Highlights of Conference on Aldosterone and the ENaC/Degenerin Family of Ion Channels

Program Examines Connection Between Fluid Regulation and Hypertension

Bethesda, Md. (Sept. 6,  2011)  The American Physiological Society is sponsoring the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, being held September 18-22 at the Asilomar Conference Grounds in Pacific Grove, Calif.  This scientific conference explores the connection between fluid balance in the body and hypertension, a growing global health concern.

The five-day program kicks off Sunday, September 18 with the keynote lecture by

Richard Lifton, Yale University School of Medicine, entitled “Aldosterone and Hereditary Hypertension.” Dr. Lifton is the Sterling Professor of Genetics and Professor of Medicine (Nephrology) and Chair, Department of Genetics, Yale University. He is also known for his groundbreaking work in identifying genes associated with blood pressure, cardiovascular disease, and bone density.

Additional conference highlights include: 

Monday, September 19

Symposia I: Structure and Function of ENaC and Related Transporters
Speakers will cover the structure, function, regulation, and molecular organization of ENaC and other transporters. Experts will discuss how aldosterone affects ENaC and the physiological importance of ENaC regulation.

Symposia II: Structure and Function of Mineralocorticoid and Glucocorticoid Receptors
Invited researchers will explain the role these receptors play in fluid balance, how these receptors function in different body tissues, and how these receptors are regulated.

Tuesday, September 20

Symposia III: Regulation of ENaC Biogenesis, Trafficking and Gating
Speakers will delve into ENaC regulation, and its interaction with and regulation by other elements.

Symposia IV: Aldosterone: Synthesis Crosstalk and Non-epithelial Actions
Researchers will make presentations on aldosterone, including the role of  nitric oxide and caveolin in the vascular actions of aldosterone and the mineralocorticoid receptor in vivo.

The Plenary Lecture will be delivered by Toshiro Fujita, University of Tokyo, Japan. It is entitled, “Role of Aldosterone and Mineral corticoid Receptor in Salt-Sensitive Hypertension and Metabolic Syndrome.” 

Wednesday, September 21

Symposia V: Remembering J.D. Horisberger and D.J. Benos
Speakers will pay tribute to two scientists whose work had a tremendous impact on the scientific community’s understanding of ion and sodium channels.

Symposia VI: Congestive Heart Failure - The Intertwined Roles of Water and Salt
Experts will explain the effects of aldosterone on the heart in congestive heart failure, and the role of ADH in water and volume abnormalities in congestive heart failure.

The Plenary Lecture will be delivered by Michael Welsh, University of Iowa and Howard Hughes Medical Institute.  It is entitled, “ASIC Structure and Function.”

Thursday, September 22

Symposia VII: ENaC Pathophysiology
Researchers will cover the evolution of ENaC and the role it plays in vascular disease, kidney disease, and cystic fibrosis.

Symposia VIII:  Aldosterone Pathophysiology
Speakers will discuss aldosterone and its relation to illnesses such as mineralocorticoid receptor mutations in human disease, and end-organ damage in primary aldosteronism.

Additional Information

The full program is available online at the APS website. Press releases about new study findings will be available on the APS press page during the conference. 

NOTE TO EDITORS: The 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels will be held September 18-22 at the Asilomar Conference Grounds in Pacific Grove, Calif. The press is invited to attend. For additional information, please contact Donna Krupa at dkrupa@the-aps.org, 3-01-634-7209.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.